STUDIES ON THE TESTES OF ALBINO RATS FOLLOWING ADMINISTRATION OF TRAMADOL HCL AND MILK

This St-l;kyolrl: the t%stes of Wi;?;f%zl;:l %‘n\s physiological effects of tramadol hydrochloride (HCL) and 08 were grouped into five cate.gorieeflty adult mqle. rats, weighing between 120 and 166 gra™ * ik only, a combination of s: control (distilled water), high-dose tramadol (10 £ k) mill onl3, 2 combnation of tramadol and milk, and low-dose tramadol (5 mg/ke). The édminisvatmn fas hi t011‘ i -Week§, after which the animals were sacrificed, and the testes were collected or his 0 ogical ana1y§1s. Histological examinations using Hemato,xylin and Eosin aining reveal.ed S:lgnlficant alterations in testicular architecture among the tramadol-treated roupS: The hlgh— it tl.‘arr%ado-l group exhibited degeneration of seminiferous tubules and pecrosis of Leyd1g cg} 1S’ indicating impaired spermatogenesis. In contrast, the milk-only group ‘maintained ortnal testlcula¥.§tmcture, suggesting no adverse effects from milk consumption. IntereSfingly’ the grofp Jeocving bf’th’ tramadol and milk showed less severe damage compared o the trama(?ol—.only T 1mP1Y?ng a potential protective effect of milk. ‘Statistical analysis highlighted significant weight differences across treatment groups, with tramadol administration jeading t0 weight reduction, while the milk-only group 'eXperienéed weight gain. The Combination Qf qamad(?l. and milk resulted in intermediate weight effects, ,indi,cating‘ that milk may mitigate tramadol-induced weight loss. In conclusion, tramadol adversely affects testicular hesth and body weight, likely through oxidative stress and disrupted spermatogenesis. However, co-administration of processed milk appears to provide protective benefits against these effects, suggesting that dietary interventions could be a viable strategy to counteract the reproductive toxicity associated with tramadol use. ‘ v j