PREVALENCE AND DETECTION OF EXTENDED SPECTRUM BETA-LACTAMASE (ESBL) PRODUCING KLEBSIELLA PNEUMONIAE FROM EKITI STATE TEACHING HOSPITAL
Abstract
Abstract
Extended-Spectrum Beta-Lactamase (ESBL)-producing Klebsiella pneumoniae poses a
significant challenge to healthcare due to its resistance to multiple antibiotics, leading to limited
treatment options. This study evaluates the prevalence and detection methods of ESBL-
producing K. pneumoniae in Ekiti State Teaching Hospital, Nigeria. Over a 12-month period, 30
clinical isolates were collected and identified using standard microbiological techniques. ESBL
production was screened using the Double-Disc Synergy Test (DDST) and confirmed by the
Combination Disk Test (CDT) and E-test, with genotypic confirmation via Polymerase Chain
Reaction (PCR) for bla_TEM, bla_SHV, and bla_CTX-M genes.
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