EFFECT OF ETHANOL EXTRACT OF IPOMOEA BATATAS (SWEET POTATOE) LEAFS ON WHITE BLOOD CELLS OF PLASMODIUM BERGHEI INFECTED MICE

ABSTRACTS This study investigates the potential of ethanol extract from Ipomoea batatas (sweet potato) leaves in modulating immune responses, particularly white blood cell (WBC) counts, in Plasmodium berghei-infected mice. The research addresses the problem of malaria-induced anemia and immunosuppression, with the objective of exploring the extract’s anti-malarial and immunomodulatory properties. Thirty-six mice, weighing 19-32g, were divided into six groups: three groups received varying doses of the extract (20 mg/kg, 25 mg/kg, 30 mg/kg), one group received artesunate (5 mg/kg), and two control groups were maintained (one parasitized but untreated, and one non-parasitized normal control). Plasmodium berghei was used to induce malaria infection, and the effect of the plant extract on parasitemia and WBC counts was assessed. Blood samples were collected post-treatment, and parasitemia levels and WBC counts were measured. The results revealed a dose-dependent reduction in parasitemia across the treatment groups. The extract suppressed parasitemia by 4%, 28%, and 66% at 20 mg/kg, 25 mg/kg, and 30 mg/kg, respectively, while artesunate showed a 62% suppression rate. Notably, the 30 mg/kg dose exhibited the highest efficacy, surpassing even artesunate in terms of parasitemia reduction. Furthermore, the WBC counts varied, with the 25 mg/kg group showing a significant reduction in WBC count, indicating an immune-modulating effect, while the highest dose (30 mg/kg) demonstrated a potential immune-boosting response. These findings are significant as they suggest that Ipomoea batatas leaf extract not only has potential anti-malarial properties but may also modulate immune function, offering a dual therapeutic benefit. The study highlights the extract’s potential as a complementary or alternative therapy for malaria, especially in regions with limited access to conventional treatments. Future research should focus on isolating the active compounds responsible for the observed effects and exploring their clinical applications in humans. This research contributes to the growing body of knowledge on plant-based treatments for malaria and provides a foundation for further exploration into traditional medicinal plants in disease management.