THE EFFECT OF THE CONCOTION OF LEAVES OF ANTIMALARIA PLANTS ON THE HISTOMORPHOLOGY OF TESTES OF WISTAR RATS

The quest for effective antimalarial remedies spans centuries, intertwined with the rich tapestry of human history and the pursuit of wellness. Traditional medicine, with a focus on the use of medicinal plants, has played a significant role throughout history. However, the historical documentation of their effects on testicular histomorphology is limited, with much of the focus centred on their antimalarial properties. The present study was aimed at assessing the effect of antimalarial plant concoction on the histo-architecture of the testes of Wistar rats. A total of 30 Wistar rats was divided into a five groups with six each were used in this study. They were administered different concentration of antimalarial plant concoction for 21days. Data analysis was done using SPSS and result were presented in tables and figures. The ethical approval of Ministry of Agriculture and Forestry was obtained. The Haematoxylin and Eosin staining of the testes of the control group, group D and E, shows the seminiferous tubule containing the terminal stage of the spermatogenic cycle all cell types are present including Sertoli cells, spermatogonia, and spermatocytes. There was different germinal layers of maturing spermatogonial cells observed, the interstitial space consisted of Leydig cells. While animals in group B and C shows the seminiferous tubules consisting of spermatids within the lumen, it also shows the germinal layer showing the Sertoli cells and different germinal maturation stages, some of the tubules are devoid of spermatids, while the interstitial spaces consist of interstitial Leydig cells. However, the antimalarial plant concotion shows no effect on the testes of wistar rats.