THEEFFECTOFETHANOLICLEAFEXTRACTOFCRASSULACEAEAND BISOPROLOLON LIPID PROFILE ON HIGH SALT FEED RAT
Abstract
The study aimed at investigating the effect of ethanolic leaf extract of crassulaceae and bisoprolol on lipidprofile(HDL,LDL, VLDL,CHO, TG),in high saltfedrats. Thirty five
(35) wistar ratsweighing 110-190 were divided into 5groupsof7 ratseach. Group 1(normal control), Group 2 (Na only) Group 3 (Cr only), Group 4 (Na + Cra) Group 5 (Na+Bis). Ethanolic leaf extract of Cr was administered orally at dose of 600mg/kg bwt, Na was administered orally at a dose of 1% in 99ml of water and 8% in 92g of feed, bisoprolol was admistered orally at a dose of 50mg/kg bwt.All the animal were given normal rat chow and water at libitum, the regimen lasted for 28 days. Thereafter, the animals were then sacrificed usingchloroformanaesthesia.Thebloodwascollectedviacardiacpunctureintosamplebottles andcentrifugedat 2500rmp for10minutes.Serumwerecollected forlaboratoryanalysis.The results of total cholesterol shows a significant level (P
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