EVALUATION OF THE LEVEL OF INTERLEUKIN 10 (IL-10) AND ITS EFFECT ON SPERM QUALITY OF MALES WITH INFERTILITY IN OSOGBO METROPOLIS, OSUN STATE.
Abstract
ABSTRACT
Infertility is a multifactorial disease affecting 15% of couples and defined as the inability to achieve spontaneous pregnancy after 12 months or more of regular unprotected sexual intercourse. The male factor is responsible for almost 50% of infertility cases, contributing equally as the female factor. The study aimed to evaluate the level of interleukin-10 (IL-10) seminal plasma of men with infertility. Eighty-eight (88) males attending fertility clinic were recruited from Uniosun Teaching Hospital, Osogbo. Anthropometric measurements and sexual characteristics were obtained using structured questionnaires and standard method. Semen samples were collected through masturbation or coitus into a sterile bottle. Sperm fluid analysis (SFA) was determined according to World Health Organization (WHO) standard. An aliquot was centrifuged, separated and stored at -20ºC. IL-10 was analyzed using Enzyme Linked Immusobent Assay (ELISA) method. Data obtained were analyzed sstatistically with Statistical Package for Social Sciences software version 22 (SPSS Inc. Chicago II. USA). The result of this study shows a significant decrease (p
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