HISTOMORPHOLOGICAL EFFECT OF SUBCHOR IONIC ADMINISTRATION OF AQUEOUS EXTRACT OF SCENT LEAVE (OCIMUM GRATISSUM) ON THE TESTIS OF ADULT WISTAR RAT
Abstract
ABSTRACT
Introduction: Medicinal plants have been utilized for centuries across various cultures for their potential health benefits. These plants contain bioactive compounds such as alkaloids, flavonoids, terpenoids, and phenolic compounds, which contribute to their pharmacological activities. Ocimum gratissimum, commonly known as "Scent leaf," is a medicinal plant rich in flavonoids. It has been traditionally used for its therapeutic benefits, including antidiabetic and antioxidant properties. The testis, or testicle, is an essential male reproductive organ responsible for the production of sperm and testosterone, the primary male sex hormone. It is a paired organ located within the scrotum, a sac of skin and muscle below the penis.
Aim: The aim of the study is to assess the subchronic administration of scent leaf (Occimum gratissimum) on the testis of adult wistar rats.
Place of study: Department of Medical Laboratory Science, College of Health Science, Joseph Ayo Babalola University, Ikeji, Arakeji, Osun State.
Method: Twenty wistar were divided into four groups [n=5] in which the Group A is the control group feed with just distilled water and feed, Group B received 300mg/kg of Ocimum gratissimum extract, Group C received 400mg/kg of Ocimum gratissimum extract and lastly Group D received 500mg/kg of Ocimum gratissimum for a period of two weeks. The animals were sacrificed through cervical dislocation and organs were harvested for Histological stains and Blood samples were also collected for full blood count. Data obtained from the study were analyzed using one-way ANOVA and subjected to graph pad prism.
Result: Shows a significant decrease in the testis weight when Group A (control) were compared to Group B (300mg/kg O. gratissimum extract). There was a significant increase in the testis weight when Group C were compared to Group B. Result also revealed that there was a significant increase in the body weight when Group B were compared to Group A.[p
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