HISTOPATHOLOGICAL EVALUATION OF SOME SELECTED HIGH BLOOD PRESSURE MEDICATIONS (AMLODIPINE AND TELMISARTAN) ON THE HEPATIC TISSUES OF ALBINO RATS

ABSTRACT The prevalence of chronic elevation of blood pressure, and the resulting morbidity, are sufficiently high to justify viewing the condition as a serious global public health problem. Sometimes lifestyle changes are not enough to treat high blood pressure, in such cases medication is required. This study performed an Evaluation on Some High Blood Pressure Medications(Amlodipine and Telmisartan) on the hepatic tissues of albino rats. A total of 18 albino rats weighing 165g-195g with high blood pressure were distributed into 3 groups (A,B and C). Group A (Labelled as control group) were administered water and food only, Group B amlodipine was given in a dose of 10 mg/kg/day for 4 weeks (28 days), Group C Telmisartan was given in a dose of 10 mg/kg/day for( 4 weeks). After 4 weeks, Animals were weighed, anesthetize and dissected and the liver harvested placed in 10% Neutral buffered formalin. A stain in hematoxylin for 3-5 minutes was done. Samples of selected sections of the liver was photographed and presented as plates. A significant increase in body weight was recorded in all groups of Amlodipine and Telmisartan treated animals. Microscopic examination of hepatic tissues from the albino rats demonstrated no obvious pathologic changes, including hypertrophy, and perivascular fibrosis, wall thickening hepatic atrophy and fibrosis, and vascular sclerosis in groups treated with Amlodipine. Histopathological examination showed no pathological glomerular, tubular, or blood vessel changes in groups treated with telmisartan during the weeks of the research. Thrust of public health policies should be primary prevention of hypertension. The long-term treatment with this combination could presents a beneficial effect on the reduction of BP, BPV, and the protection of end- in-depth study on the effect of these antihypertensive drug treatments on the antioxidant mechanisms involved as liver damage is highly recommended.