IMPACT OF NARINGENIN FRACTIONATE OF MELON SEEDS EXTRACT ON THE PANCREAS OF MICE MODELS.

ABSTRACT This study investigates the impact of naringenin fractionate from melon seeds extract on the pancreatic health and weight of mice, focusing on histological changes and overall weight. Twenty (20) adult mice were divided into three groups: a control group and two treatment groups receiving 0.3mg/kg and 0.5mg/kg naringenin fractionate from melon seeds extract. The treatment was administered over a period of 48 days. The body weights of the mice were recorded weekly. At the end of the treatment period, the mice were euthanized, and their pancreases were harvested for histological examination. The treatment group exhibited a significant increase in body weight compared to the control group (p < 0.05). However, histological analysis of the pancreatic tissues revealed no significant changes between the control and treatment groups. The pancreatic architecture, including the acinar cells, islets of Langerhans, and ductal structures, appeared normal and comparable across all the groups. In conclusion, the naringenin fractionate from melon seeds extract led to a significant increase in body weight in mice models. Despite this weight gain, there were no significant histological changes observed in the pancreatic tissues. These findings suggest that while naringenin fractionate may influence metabolic parameters, it does not adversely affect pancreatic histology in mice models. Further studies are warranted to explore the mechanisms underlying the weight increase and to assess the long-term effects of naringenin fractionate on other organs and overall metabolic health. Keywords: Naringenin, melon seeds extract, pancreas, histology, body weight.