CUCURBITA PEPO SEED OIL PREVENTS METHOTREXATE INDUCED ACETYLCHOLINESTERASE INHIBITION AND POSSIBLE GLUTAMATE NEUROTOXICITY IN MALE WISTAR RATS
Abstract
Methotrexateisafoli
cacidantagonist,wi
treatmentofvari
delyusedasachemotherapeuticagentinthe
ouscancerousstages(leukaemia,l
ymphoma,osteosarcoma,headand
necktumours,lungcancer,breastcancer,etc.)andinthetreatmentofvarious
infl
ammatorydiseases(Ozoguletal.,2013;Kumarietal.,2016).Iti
salsousedforthe
treatment of multiple sclerosis,dermatomyositis,sarcoidosis,psoriasis,and
rheumatoid arthriti
s,disorders causing inflammation.Its side effects include
hypersensiti
vitypneumonia,centralandperipheralnervoussystem toxici
ty,li
veran
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