COMPARATIVESTUDYOFTHEEFFECTSOF20%ROASTEDSESAME SEEDS(SESAMUM INDICUM)DIETANDPLANTAIN(MUSAPARADISIAICA) ONKIDNEYFUNCTIONINSTREPTOZOTOCIN-INDUCEDDIABETIC RATS.
Abstract
ThestudywascarriedouttoevaluatethepotentialbenefitsofSesamum indicum
dietandaqueousextractofMusaparadisiacaonkidneyfunctioninstreptozotocininduceddiabeticrats.
Theevaluationofthisstudywascarriedoutfortwenty-one(21)
days.Forty(40)wisterratsweighing120to160gwereassignedintoeight(8)study
groups.Group1:Normalcontrol(NC),Group2:Diabeticcontrol(DC),Group3:
Standarddrug(STD),Group4:20%roastedsesameseeds,Group5:diabetic+20%
roastedsesameseeds,Group6:200mgplantain,Group7:Diabetic+200mgPand
Group8:Diabetic+200mgP+20%ROB.Distilledwaterwasmeasuredupto1000mL
usingagraduatedcylinderandwasaddedonto400gofpowderorgrinderPlantain
andwasallowedfor48hours.After48hr,liquidextractwascollectedusingmuslin
clothandchaffwasdiscarded.Theextractwassubjectedtodryinginawaterbath
fortwoweeksandphytochemicalsofPlantainwereobtained.Thedriedbeniseeds
wereroastedunderagentlefirewithflyingpanandlatermilledusingmortarand
pestletogetthepowderwhichwasmixedwiththefoodfortheexperimentalrats.
Hundred(100ml)ofwaterand10goffructosewasmixedtogetherthoroughlyand
administeredtotheAnimalsforaperiodoftwoweeksandinductionofdiabeteswas
doneusing40mg/kgofStreptozotocinfreshlydissolvedincitratebufferofPH4.5.
AfterDiabeteswasinducedtotheanimals,Beniseedandaqueousextractsof
plantainwereusedtomanagethediabetesfor21days,afterwhichtheanimalswere
sacrificed,bloodwascollectedfrom theheartthroughcardiacpuncture.Theblood
wascentrifugedandserum wascollectedforanalysisofurea,creatinine,BUNand
uricacid.Thestudyrevealedasignificant(P
Full-Text Access Notice
In accordance with the NERD Policy on promoting peer-reviewed publication, public access to the full text of a project, thesis or dissertation is restricted for three years, allowing the author and supervisors sufficient time to pursue peer-reviewed publication.
During this period, researchers with legitimate academic or research purposes may request authorisation directly from the author to enable NERD to release the indexed full texts of the work using the form below.