ANTIMICROBIAL ACTIVITIES OF VERNONIA AMYGDALINA (BITTER LEAF) EXTRACT AGAINST EXTENDED SPECTRUM BITTER LACTAMASE PRODUCING BACTERIA
Abstract
ABSTRACT
Extended spectrum Beta-Lactamase (ESBL) producing bacteria are becoming difficult to treat because they resist many common antibiotics. This study examined the antibacterial effect of Vernonia amyygdalina (bitterleaf) extract on ESBL-producing bacteria. Bitterleaf samples were prepared, and both aqueous and ethanolic extracts were tested using standard laboratory methods to measure their zones of inhibition. The findings showed that bitterleaf extract was able to inhibit the growth of ESBL producing bacteria with the ethanolic extract showing stronger activity than the aqueous extract. This suggests that ethanol extracts more effective bioactive compounds from the plant. Overall, the study indictes that Vernonia amygdalina has potential as a natural antimicrobial agent against ESBL-producing bacteria. More research is recommended to isolate the active compounds and asses the clinical usefulness
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