EVALUATION OF DICLOFENAC SODIUM CREAM FORMULATED USING EXTRACTED CASTOR OIL (RICINUS COMMUNIS L.)
Abstract
ABSTRACT
INTRODUCTION: Topical drug administration is a localized drug delivery system anywhere in the body through the skin as topical route (Sudhir Bharadwaj et al; 2012). Creams are semi-solid emulsions intended for external application.
They are often composed of two phases. Oil-in-water (o/w) emulsions are most useful as water-washable bases, whereas water-in-oil (w/o) emulsions are emollient and cleansing agents. Upon pharmaceutical application creams have shown to be of undeniable great importance in treatment of various health conditions as when necessary.
AIM
• To evaluate diclofenac sodium cream formulated using extracted castor oil (Ricinus community).
OBJECTIVES
• To extract castor oil from castor bean seed.
• Characterization of extracted castor oil.
• Diclofenac cream formulation using extracted castor oil and commercially available arachis oil.
• Evaluate cream formulated
METHODS: Collection and identification of plant material
• Extraction of castor oil
• Preparation of aqueous phase
• Preparation of oily phase
• Characterization of extracted oil
• Evaluation of the diclofenac sodium creams formulated
RESULT: The results showed castor oil as a suitable option for production of diclofenac cream in comparison to one formulated with arachis oil and other
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