STUDY OF NARINGENIN FRACTIONATE OF MELON SEEDS EXTRACT ON THE MICRO-ANATOMY OF THE SPLEEN OF ANIMAL MODELS

This study investigates the offect of study of naringenin fractionate of melon seeds my of the spleen of animal models, focusing mice were divided into three groups: a on histological extract on the micro-anato changes and overall weight. Twenty (20) adult 0.3mg/kg and 0.5mg/kg naringenin wo treatment groups receiving control group and t xtract. The treatment was fractionate from melon seeds ¢ 2dministered over a period of 48 days. The body weights of the mice were recorded we nized, and their spleen were harvested for ckly. At the end of the treatment period, the mice were eutha amination. The treatment group exhibited a s < 0.05). the histology of the spleen was he hematoxylin and eosin chiff histological ex ignificant increase in body weight compared to the control group (p ing the hematoxylin staining techniques, also ficantly different from the periodic acid s o significant changes in the analyze us stain photomicrographs were signi owever, micro-anatomy of the spleen revealed n micro-anatomy of the spleen in the nar sue. These findings suggests stains. H control and low dose group. The, dose (0.5mil) group shows a focal necrotic areas in the tis e metabolic processes, appetite regul es, naringenin maintained the igenin high that naringenin may influenc ation, or energy rage, leading to weight gain. Also, at lower dos pleen, indicating its potential protective effects oses of naringenin led to the Sto normal architecture of the s lular damage and inflammation. While the high d ¢ areas in the spleen. This suggests that while naringenin e may have negative eftects against cel development of focal necrotl has beneficial properties at lower doses, excessive intak on the spleen.