SUBACUTE TOXICITY STUDIES OF METABOLIC EXTRACT OF DACRYODES EDALIS IN WISTER RATS: A STUDY OF HAEMATOLOGICAL CHANGES
Abstract
This study evaluates the toxicity of aqueous and methanol extracts of Dacryodesedulis seed in
Wistar rats. These eds were locally obtained from a farmer in the Olobo area of Benin City,
Edo State, Nigeria, and identified by a botanist. A total of 45 Wistar rats were divided into nine
groups, each consisting offive rats. Group A served as the control, while Groups B, C, D, and E
received 250, 500, 1000, and 2000 mg/kg of the aqueous extract of D. edulis seed, respectively.
Similarly, Groups F, G, H, and I were administered 250, 500, 1000, and 2000 mg/kg of the
methanol extract via oral gavage for 28 days. Acute toxicity assessment revealed that the LD50
of both extracts exceeded 5000 mg/kg, as no mortality was observed at this dose, except for a
reduction in normal activity in animals administered 5000 mg/kg. Administration of 250, 500,
and 1000 mg/kg of both extracts showed no significant effect on the evaluated parameters
compared to the control group. However, adose of 2000 mg/kg of both aqueous and methanol
extracts significantly (p
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