HISTOMOPHOLOGICAL EFFECT OF SUBCHORIONIC ADMINISTRATION OF AQUEOUS EXTRACT OF SCENT LEAF (OCIMUM GRATISSIMUM) ON THE PANCREAS OF ADULT WISTAR RAT
Abstract
ABSTRACT
Medicinal plants have been a staple of traditional medicine for ages, providing a wealth of bioactive chemicals with potential medicinal benefits. Ocimum gratissimum, often known as scent leaf, is a tropical plant that has been used in traditional medicine to treat a variety of conditions. The pancreas is an important organ that regulates glucose and facilitates digestion. It is located behind the stomach.
Aim: This study aims to investigate the histomorphological effect of the subchronic administration of Ocimum gratissimum (scent leaf) on the pancreas of an adult Wistar rats
Methods: Twenty wistar were divided into four groups [n=5] in which the Group A is the control group feed with just distilled water and feed, Group B received 300mg/kg of Ocimum gratissimum extract, Group C received 400mg/kg of Ocimum gratissimum extract and lastly Group D received 500mg/kg of Ocimum gratissimum for a period of two weeks. The animals were sacrificed through cervical dislocation and organs were harvested for Histological stains and Blood samples were also collected for full blood count. Data obtained from the study were analyzed using one-way ANOVA and subjected to graph pad prism.
Result: The pancreas weight shows a significant decrease in the lower dose and higher dose (F= 25.65; P
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