ANTIMICROBIAL ACTIVITY OF ALOE VERA (ALOE BARBADENSIS MILLER) LEAF EXTRACT AGAINST SELECTED CLINICAL ISOLATES
Abstract
ABSTRACT
The increasing threat of antimicrobial resistance has necessitated the exploration of alternative therapeutic agents, particularly from natural sources. This study investigates the antimicrobial activities of Aloe vera (Aloe barbadensis Miller) leaf extract against selected clinical. Fresh Aloe vera (Aloe barbadensis Miller) leaves were collected, dried, and extracted using cold maceration with ethanol. Qualitative phytochemical screening revealed the presence of bioactive compounds including alkaloids, flavonoids, tannins, saponins, anthraquinones, and phenolic compounds. Antimicrobial activity was assessed using the agar well diffusion method against four clinical isolates: Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. The ethanolic extract demonstrated varying degrees of inhibition, with the highest zone observed against Candida albicans (20.5 mm) and the lowest against Staphylococcus aureus and Pseudomonas aeruginosa (13.5 mm each). These results suggest that Aloe vera (Aloe barbadensis Miller) contains significant phytochemicals with notable antimicrobial potential, supporting its traditional medicinal use and highlighting its promise as a cost-effective alternative in the development of plant-based antimicrobial agents.
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