ANTIFUNGAL SUSCEPTIBILITY PROFILE OF CANDIDA SPECIES CAUSING CANDIDURIA AMONG HOSPITALIZED DIABETIC PATIENTS IN FEDERAL TEACHING HOSPITAL, OWERRI
Abstract
This study Antifungal Susceptibility Profile of Candida Species Causing Candiduria Among Hospitalized Diabetic Patients in Federal Teaching Hospital, Owerri is aim to isolate and identify Candida species from urine samples of hospitalized diabetic patients using conventional microbiological methods and to determine the antifungal susceptibility profiles of the isolated Candida species against fluconazole, ketoconazole, amphotericin B, nystatin, clotrimazole and caspofungin. Candiduria is the presence of Candida species in urine and is increasingly prevalent among hospitalized diabetic patients. Urine samples were collected from hospitalized diabetic patients and analyzed using conventional microbiological methods. Virulence factors which includes phospholipase, proteinase, hemolysin and biofilm formation potentials were evaluated. Antifungal susceptibility testing was carried out using fluconazole, amphotericin B, nystatin, ketoconazole, clotrimazole and caspofungin. The Results showed that Candida albicans was the most prevalent species (50.9%), followed by Candida parapsilosis (22.8%), Candida tropicalis (19.3%), and Candida glabrata (7.0%). Non-albicans Candida species demonstrated variable resistance patterns, particularly to fluconazole. Virulence factor analysis showed that C. albicans exhibited high phospholipase and hemolysin activity compared to NAC species. The study highlights the importance of species-level identification and antifungal susceptibility testing in guiding effective management of candiduria. The findings emphasize the importance of species-level identification and routine antifungal susceptibility testing to guide effective treatment, reduce the risk of resistance, and improve clinical outcomes in diabetic patients with candiduria.
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