THE EFFECT OF HESPERIDIN ON THE CORTISOL LEVEL OF PSYCHOLOGICAL STRESS-INDUCED PTSD WISTAR RATS.
Abstract
ABSTRACT
This study investigates the effect of hesperidin on the cortisol levels of psychological stress-induced PTSD Wistar rats following the administration of hesperidin to PTSD rats. This research aims to determine the effect of Hesperidin on the Cortisol level of psychological Stress-Induced PTSD in Adult Wistar Rats. Thirty healthy male Wistar rats weighing between 210-280g were divided into 6 groups: I, II, III, IV, V, and VI with each group consisting of 5 animals. Group I was regarded as the control group and took normal saline, Group II was regarded as the negative control group (stress-only group) and was not treated, Group III: stress + fluoxetine group, was administered 10mg/kg according to their body weight. Group IV: stress + hesperidin low dose, was administered hesperidin 50mg/kg. Group V: stress + hesperidin medium dose, was administered 100mg/kg. Group VI: received 200mg/kg respectively, and
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