MODULATORY EFFECT OF METHANOLIC EXTRACT OF AIDAN FRUIT ON CARDIOVASCULAR RISK FACTORS USING OXIDATIVE STRESS AND LIPID PEROXIDATION BIOMARKERS IN WISTAR RATS
Abstract
The study was aimed at investigating the modulatory effect of methanolic extract of Aidan fruit
on card ovascular factor using oxidative stress and lipid peroxidation Biomarkers in Wistar rats.
Fificen (15) male Wistar rats weighing (90-150g) were used for the study. The rats where selected
according to their body weight and divide into three (3) groups containing five (5) Wistar rats each.
Group | was normal control group and was fed with normal rat feed and 0.2m. of distilled water,
Group 2 was administered with low dose (LD) methanolic extract of Aidan fruit 400mg/kg. while
Group © was administered with high doe (HD) methanolic extract of Aidan fruit 800mg/kg using
oropharyngeal cannulas. All the animals had free access to food and water. The administration was
carried out every day tor the period of 14 days after which the animals were sacrificed. The SOD.
CAT. MDA and LDH were used as biomarkers for oxidative stress and lipid peroxidation. The
dats obtained was subjected 10 statistical analysis using ANOVA. The result showed no significant
difference in SOD concentration across the three (3) groups, though there was a marginal increase
within the low and high dose methanolic extract of Aidan fruit groups as compared to control
group. Catalase (CAT) activity showed a significant increase (p
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