PROTECTIVE ACTIVITES OF VITAMIN C AND VITAMIN E ON ALUMINUM CHLORIDE-INDUCED TESTICULAR TOXICITY IN ADULT MALE WISTER RAT
Abstract
This study aims to investigate the protective role of Vitamin C and Vitamin E on Wistar
rat; following aluminium chloride induced testicular damage adult male Wister rats and
it’s objective is to assess and evaluate the effect of Vitamin C and Vitamin E on Wistar
rat; following aluminium chloride induced testicular on body weight, sperm parameters,
histology and hormones.
A total of twenty-five male rats were divided into five groups of five rats each. Group A
is control and was fed with rat chow, Group B is AICI3, Group C is AICI3 + Vitamin E,
Group D AICI3 + Vitamin C and Group E is AICI3 + Vitamin C + Vitamin E. The
treatment was giving respectively for a period of 3 weeks. Body weight was weighed at
start, every week and end of the experiment using digital weighing scale. At the end of
the experiment, blood sample were obtained through the cardiac puncture. The blood was
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collected into plain bottles and centrifuge for blood hormonal analysis. The histology of
the testis and epididymis was carried out.
The result showed that there was an increase in the weight of the rats that was
administrated Vitamin C and E compared to the rats administrated AICI3 only. The
reproductive hormones such as follicle stimulating hormone, luteinizing hormones and
testosterone were affected by AICI3 in Group B.
Putting together results from this study, we concluded that AICI3 has no negative effect
on weight, hormonal profile and sperm parameter. This is further supported by the
histology of the testis and epididymis, sperm status and the hormonal profile of the male
rats.
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