EFFECT OF MILLET BOUND POLYPHENOLS ON CALCIUM AND MAGNESIUM AND CHLORIDE LEVELS OF HYPERGLYCAEMIC RATS
Abstract
ABSTRACT
Title: Effects of Millet-Bound Polyphenols on Calcium, Magnesium and Chloride DuringPregestational Hyperglycemia on Wistar Rats
Background: Pregestational hyperglycemia is a major risk factor for complications during pregnancy. Rich in polyphenols, millet is a nutrient-dense cereal that may have therapeutic benefits for metabolic conditions. This study outlines the impact of millet-bound polyphenols on calcium, magnesium and chloride duringpregestational hyperglycemia in wistar rats.
Methods: Six groups of wistar rats were created, millet-fed, hyperglycemic, control, and millet-fed hyperglycemic. Hyperglycemia was induced using a high-glucose meal. The corresponding groups received millet-bound polyphenols for a period of six weeks. Following euthanasia, routine biochemical assays were used to assess for magnesium, calcium, and chloride
Results: Pregestational hyperglycemia led to significant alterations in electrolyte levels and lipid profiles in fetal neuroepithelial tissues, with elevated sodium and cholesterol levels and reduced potassium and HDL cholesterol. Millet-bound polyphenols mitigated these changes, normalizing electrolyte balance and lipid profiles. Notably, the millet-fed hyperglycemic group showed significant improvements in electrolyte homeostasis and lipid metabolism compared to the hyperglycemic control group.
Conclusion: Millet-bound polyphenols have an effect on electrolyte balance and lipid profiles in fetal neuroepithelial tissues. These findings suggest that millet may offer a protective strategy against metabolic disturbances in hyperglycemic conditions, with implications for maternal and fetal health.
Keywords: Millet, Polyphenols, Pregestational Hyperglycemia, Electrolytes, Calcium, Magnesium, Chloride,Wistar Rats.
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