PROTECTIVE EFFECTS OF ETHANOL EXTRACT OF PERSEA AMERICANA SEED ON LIVER DAMAGE IN WISTAR ALBINO RATS
Abstract
This study was carried out to investigates the protective effect of ethanol extract
Persea americana (avocado) seed on liver function in Lead acetate-induced liver
damage in Wister Albino rats.The twenty-five Wister albino rats weighing 80.4g to
200g were used for the study. They were allowed to acclimatized for one week
with free access to feed and water. After acclimatization, they were randomly
distributed into five groups (A, B, C, D and E) of 5 rats each. The administration of
the seed extract was oral with the aid of an intubation tube. The group received
different dose of ethanol extracts of Persea Americana as follows, Group A was
normal control, Group B was silymarin (standard drug), Group C received
100mg/kg bodyweight of Persea Americana, Group D were treated with 150mg/kg,
Group E were treated with 200mg/kg bodyweight of the seed extract. At the end of
the 14 days, the blood sample were collected from the rats through ocular veins for
biochemical analysis using the standard method. The result of liver function profile
of lead acetate revealed that therewas a significant increase in alanine
aminotransferase (ALT)activity of all the rats treated with extract and silymarin
when compared with the control group. There was also significant increase in
alkaline phosphatase (ALP) level of the rat treated with silymarin when compared
with the normal control group. The result also showed that there was a significant
decrease in aspartate aminotransferase (AST) level of the rats treated with
200mg/kg bodyweight of extract when compared to normal control group. The
result of the study suggested that the seed extract is not toxic to the liver and could
be useful treatment of liver damage.
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