ANTIBIOGRAM OF ESCHERICHIA COLI AND PROTEUS MIRABILIS ISOLATED FROM WOUNDS IN PATIENTS ATTENDING SPECIALIST HOSPITAL BAUCHI, BAUCHI STATE
Abstract
Wound infection represents a significant clinical challenge, contributing to delayed
healing, prolonged hospital stays, and increased healthcare costs. This study aimed
to isolate, identify, and determine the antibiotic susceptibility patterns of bacteria
associated with wound infections in patients attending the Specialist Hospital,
Bauchi, Nigeria. A total of thirty wound swab samples were collected and analyzed
using standard microbiological techniques, including Gram staining and
biochemical tests (Indole, Citrate utilization, and Triple Sugar Iron tests). Antibiotic
susceptibility was determined using the Kirby-Bauer disc diffusion method in
accordance with Clinical and Laboratory Standards Institute (CLSI) guidelines.
Proteus mirabilis and Escherichia coli. Both isolates exhibited multidrug resistance,
particularly to beta-lactams (Amoxicillin, Gentamycin) and cephalosporins
(Cefotaxin). Proteus mirabilis was sensitive only to Levofloxacin (22 mm) and
Ciprofloxacin (18 mm), while E. coli was sensitive to Levofloxacin (30 mm),
Augmentin (16 mm), and Azithromycin (15 mm). The predominance of resistance
among these isolates aligns with global reports of rising multidrug-resistant
Enterobacteriaceae and underscores the need for regular antibiogram updates. These
findings highlight the limited efficacy of commonly prescribed antibiotics and
emphasize the importance of using fluoroquinolones, such as Levofloxacin, for
empirical therapy in this setting. The study recommends routine antibiotic
susceptibility surveillance, strict antimicrobial stewardship, and enhanced infection
control practices to mitigate the spread of multidrug-resistant pathogens in wound
management
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