MOLECULAR EVALUATION OF HUMAN PAPILLOMAVIRUS TYPE 11 AMONG WOMEN AT FMC YENAGOA, BAYELSA STATE

Cervical cancer is a major burden in Nigeria and Human Papilloma Viruses (HPV) are the etiological agents of cervical and different anogenital malignancies. Over 100 differing kinds of HPVs are familiar up to now, and each one target epithelial tissues for infection. One-third of HPV varieties specifically infect the genital tract and a group of these is that the activating agents of anogenital cancers. Human papilloma viruses are majorly divided into high risk and low risk type and HPV11 is characterized into the low risk type. HPV11 affect the sex organ tract and induce benign hyperproliferative lesions or sex organ warts. Around eightieth of sexually active men and ladies will contract the HPV11 virus at some levels throughout their lifetime. The aim of this study was to evaluate the prevalence of HPV 11 subtype in a group of cervical cancer tissues in FMC Yenagoa and in this work, results shows that 80% of the tested samples were positive for the human papilloma virus with 63% of the positive cases been human papilloma virus 11 subtype. HPV11 virus affects the basal cells of stratified epithelia. This study was used to evaluate the percentage of HPV and typing of human papilloma virus type 11 using polymerase chain reaction. A Non-probability sampling method was used for study, with a total of 20 formalin fixed paraffin embedded cervical tissue blocks randomly selected from the department of histopathology archives of Federal Medical Center (FMC) Yenagoa used for the study. The result of this research has shown that HPV11 subtype is one of the common subtype responsible for anogenital warts and oral papillomatosis and it’s importance for consistent cervical screening and pap test especially for women of African region.