EVALUATION OF RENAL IMPAIRMENT AND GLOMERULAR FILTRATION RATE AMONG TYPE 2 DIABETIC PATIENTS IN ABA ABIA STATE

Diabetic mellitus (DM) is a group of metabolic disorder of carbohydrate metabolism in which glucose is underused, producing hyperglycemia. It is the major cause of renal morbidity and mortality, and diabetic nephropathy is one of chronic kidney failure. The aim of this study was to evaluate serum urea, uric acid and creatinine in diabetes mellitus patients. The study included 100 patients, 50 patients with confirmed Diabetes Mellitus of both sexes diagnosed with diabetes for more than one year as well as 50 non-diabetic subjects. DM patients were diagnosed as per the guidelines of the American Diabetes Association, where diabetes was considered if patients had a fasting blood glucose level of ≥126mg/dl (7.0 mmol/L). The diabetic patients had a mean age of 38.88±0.84 years while the non-diabetic subjects had a mean age of 38.22±0.84 years. Uric acid was significantly increased in diabetic patients when compared with the non-diabetic subjects p0.05 t = -0.656, p=0.515 and creatinine, t = -0.888, p = 0.379. Out of the 50 diabetic patients in this study 8% had abnormal glomerular filtration rate while 92% had normal glomerular filtration rate and there was no significant difference in glomerular filtration rate when compared within the control and the subjects p >0.05 t = 5.433 p= 0.164. There was a negative correlation between urea and fasting blood sugar P>0.01 r = -0.089 and p= 0.367, there was a negative correlation between creatinine and fasting blood sugar P>0.01 г-0.197 p =0.171and both were not statistically significant. Uric acid was positively correlated with fasting blood glucose and was statistically significant p