ANTIBACTERIAL ACTIVITY OF SECONDARY METABOLITES FROM ACTINOMYCETES ISOLATED FROM DIFFERENT SOIL SAMPLES IN IKERE EKITI
Abstract
ABSTRACT
This study investigates the antibacterial activity of secondary metabolites produced by actinomycetes isolated from soil samples collected from different locations in Ikere Ekiti, Nigeria. Actinomycetes are a diverse group of microorganisms known for their potential to produce bioactive compounds with antimicrobial properties. Soil samples were systematically collected and cultured on selective media, leading to the isolation of actinomycetes strains. The antimicrobial activities of the isolated strains were evaluated against a range of pathogenic bacterial strains using the agar well diffusion method. The results revealed that several actinomycetes strains exhibited significant antibacterial activity, with some isolates showing strong inhibition against both Gram-positive and Gram-negative bacteria. These findings highlight the rich microbial diversity in the soils of Ikere Ekiti and suggest that actinomycetes from this region could be a valuable source of new antibiotics for combating bacterial infection.
Keywords: Microbial diversity, Actinomycetes, Secondary metabolites, Antibacterial activity
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