ANTIBIOGRAM OF STAPHYLOCOCCUS AUREUS, ESCHERICHIA COLI AND PSEUDOMONAS AERUGINOSA ISOLATED FROM URINARY TRACT AND BLOOD CULTURE SPECIMENS IN UNIVERSITY OF CALABAR TEACHING HOSPITAL CALABAR, NIGERIA
Abstract
The increasing rate of antimicrobial resistance due to excessive use of antibiotics has
become a global challenge to the healthcare providers. This challenge has made it
necessary to constantly document the susceptibility pattern of pathogens implicated in
infections to enable quality case management. This study was however designed to
assess the current antibiogram of Staphylococcus aureus, Escherichia coli and
Pseudomonas aeruginosa isolates from genitourinary tract and blood culture specimens.
Ten (10) isolates each of S. aureus, E. coli and P. aeruginosa were obtained from the
Microbiology and Parasitology Laboratory of University of Calabar Teaching Hospital
and investigate for their antimicrobial susceptibility pattern. The Kirby-Bauer diffusion
method was used to assess the antimicrobial susceptibility profile of eight commercially
prepared antibiotics. Out of 10 E. coli isolates investigated, 70% were most susceptible
to levofloxacin, followed by 60% each to ceftazidime and gentamycin. The isolates were
least susceptible to meropenem and cefiriazone with 40% susceptibility rate each. Also,
of the 10 Staphylococcus aureus isolates investigated, the highest susceptibility rate of
80% was reported with meropenem while the isolates were least susceptible (40%) each
to erythromycin and penicillin. For Pseudomonas isolates, the highest susceptibility rate
of 60% was reported with gentamycin. The isolates were most resistant to meropenem
with only 20% susceptibility rate. This study has shown that, the gram negative
organisms were more resistant to meropenem while the gram positive isolates were
mostly resistant to erythromycin and penicillin, respectively. Although the application of
empirical treatment is an important approach in clinical care, in this study it is
recommended that, antimicrobial susceptibility testing should always be conducted to
determine the susceptibility pattern of an infecting agent for proper treatment.
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