EVALUATION OF ANTIDEPRESSANTS EFFECT OF GUIERA SENEGALESIS ETHANOL LEAF EXTRACT IN MICE USING FORCED SWIMMING TEST
Abstract
ABSTRACT
Depression is a mood disorder characterized by persistent feelings of sadness, loss of interest in activities, and cognitive impairments such as difficulty with thinking, memory, eating, and sleeping. It is a common mental health disorder that affects millions of people worldwide and is associated with significant functional impairment in daily life. Guiera senegalensis holds significant value in traditional African medicine, where various parts of the plant (leaves, bark, roots) are used to treat a wide range of ailments. This study evaluates the antidepressants effect of Guiera senegalesis leaf extract using forced Swimming test. The phytochemical and LD50 determination of the extract were conducted using a standard protocol.
Guiera senegalesis in this work, reveals the presence of tannins, saponins flavonoids alkaloids were as steroids were absent. The LD50 of the extract was 5000mg/kg. According to statistical analysis a significant antidepressants effect in the extract treated group at dose dependent (1500,750&357 mg/kg), compared to control group. This study suggest that Guiera senegalesis leaf extract may exhibit promising therapeutic potential in mitigating depression.
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