QUALITY ASSESSMENT OF SOME SELECTED BRANDS OF AMLODIPINE TABLETS IN RIVERS STATE, BAYELSA STATE, AND DELTA STATE, NIGERIA
Abstract
Amlodipine is a calcium channel blocker that is widely used to treat hypertension, which is a chronic health condition characterized by persistent elevated pressure of blood in the arteries. Hypertension is a predisposing factor to stroke, kidney failure, heart diseases and vision loss. The large demand for amlodipine makes it a good candidate for fakers. Consumption of substandard and/or fake amlodipine tablets will have a negative impact on the management of hypertension. This justifies continuous monitoring of amlodipine preparations in the marketplace and the provision of simple and cost-effective assay methods that could be routinely utilized for their assay. Six different brands of amlodipine tablets were qualitatively assessed for uniformity of weight, friability, hardness, and disintegration using standard physical methods. The six (6) brands met the official requirements for uniformity of weight; all the (6) brands passed the friability test and Three (3) brands met the official requirement for hardness tests. All the brands tested passed the disintegration test. The assay method used in this study is reliable, simple and cost-effective and can be routinely used to assay amlodipine tablets.
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