MEDICINAL IMPACT OF BITTER LEAF EXTRACT AND ITS METAL II COMPLEXES ON MEASLES

ABSTRACT Donkwa, a traditional Nigerian snack made primarily from maize and groundnut, is popular for its convenience but lacks essential nutrients, particularly protein, fats, and micronutrients. In light of prevalent malnutrition in West Africa. This study aimed to enhance Donkwa's nutritional profile by incorporating finger millet (Eleusine coracana), a cereal rich in calcium, iron, dietary fiber, and bioactive compounds. The study evaluated the antioxidant properties and bioactive potential of Donkwa formulated with finger millet flour. The preparation involved mixing finger millet flour with groundnut and spices, followed by methanol extraction of bioactive compounds. Phytochemical analyses quantified total phenolics, flavonoids, tannins, and saponins, while antioxidant activities were assessed using DPPH, ABTS, and FRAP assays. Additionally, enzyme inhibition assays were conducted to evaluate the effects on α-amylase, α-glucosidase, and pancreatic lipase. Results showed that the finger millet-enriched Donkwa, particularly the sample with Gedanmia (FMD-Gedanmia), had significantly higher levels of bioactive compounds and superior antioxidant activities compared to the control. The FMD-Gedanmia sample also demonstrated strong enzyme inhibitory effects, suggesting potential benefits in glycemic control and obesity management. This study concludes that incorporating finger millet into Donkwa substantially enhances its nutritional and bioactive properties, positioning it as a functional food with therapeutic potential. The findings support the promotion of finger millet-based Donkwa as a valuable dietary option for improving public health outcomes in West Africa. Further research and public health initiatives are recommended to promote its consumption.