EFFECTS OF PROPIONIC ACID ON KIDNEY OXIDATIVE STRESS MARKERS IN HIGH-FAT-DIET STREPTOZOTOCIN-INDUCED MALE WISTAR RATS
Abstract
Diabeticnephropathy(DN)occursduetouncontrolledhyperglycemia whichinturnleadstoreactiveoxygenspeciesgeneration(ROS)whichplay key roleinDNpathogenesis.Thisstudy investigatedtheeffectofpropionicacidonkidneyoxidativestressmarkersinhigh-fat-dietstreptozotocin-induc eddiabetic rats.
Thirty-two(32)maleWistarratsweighing(220±20g)wereused.Diabete swasinducedbyintra-peritonealadministrationofrepeatedlow-dosesofs treptozotocin(30mg/kg)afterfeedingtheratswithhigh-fat-diet(HFD)for eightweeks.Theywvererandomizedintofourgroups(n=8);Control(CON),C ontrol+60mg/kgpropionicacid(CON+PROP),,DM(HFD+STZ)andDM+60mg/kg propionicacid(DM+PROP)..Theyweretreatedfor4weeksviaoral-routeofdr ug-administration.Feedandwaterintakewererecordeddaily.Body-weight andfasting-blood-sugar(FBS)weremonitoredweekly.Animalsweresacrifice dunderketamine-anesthesia(50mg/kg),bloodwascollectedbycardiac-pu nctureandkidneyswereharvestedforbiochemicalexamination.Plasmainsulin,catalase(CAT),Glutathione(GSH),superoxidedismutase(SOD)andmalon dialdehyde(MDA)wereexamined.DatawasexpressedinMean±S.E.Mand analyzedusingGraph-padprismversion5.0.One-way-analysisofvariance(A NOVA),followedbyTukey'sposthoctestwasdone.Resultsp
Full-Text Access Notice
In accordance with the NERD Policy on promoting peer-reviewed publication, public access to the full text of a project, thesis or dissertation is restricted for three years, allowing the author and supervisors sufficient time to pursue peer-reviewed publication.
During this period, researchers with legitimate academic or research purposes may request authorisation directly from the author to enable NERD to release the indexed full texts of the work using the form below.