EFFECT OF KOLAVIRON ON HEME OXYGENASE AND JAK/STAT SIGNALLING IN BIFENTHRIN INDUCED TESTICULAR TOXICITY IN WISTAR RATS
Abstract
This study is designed to evaluate the effect of kolaviron on heme oxygenase and JAK/STAT
signaling in bifenthrin induced testicular toxicity in wistar rats. Thirty-five (35) rats from the
pool of forty (40) rats induced with BPH were arbitrarily divided into five (5) sample groups
(groups 2-6) consisting of seven (7) rats each, whereas seven rats (non-induced) constituted
group one. Group one(normal control): 0.5m of vehicle (Tween 80 + Canola Oil in the ratio
1:10). Group II: 5Smg/kg body weight testosterone + 0.5ml of vehicle. Group lll: 5Smg/kg body
weight testosterone + 150mg/kg body weight kolaviron .Group IV: 5mg/kg body weight
testosterone + 15mg/kg body weight quercetin. Group V: 5mg/kg body weight testosterone +
|50mg/kg body weight kolaviron + 15mg/kg body weight quercetin. Group VI: Smg/kg body
weight testosterone +5mg/70kg body weight Finasteride. After twenty eight days of treatment
with placebo, kolaviron and quercetin, and Finasteride, the treatments were withdrawn, and
twenty four hours after the last dose administration and after a twelve hour fast, all animals were
sacrificed under chloroform anaesthesia. The result displayed a positive restoration in testicular
catalase activity, testicular GPS activity, testicular GSH level, testicular NF-KB activity,
testicular GST activity.
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