THE EFFECT OF AQUEOUS EXTRACT OF TERMINALIA CATAPPA LEAF OF HAEMOSTATIC INDICES OF CYCLOPHOSPHAMIDE INDUCED IMMUNOCOMPROMISED RAT
Abstract
Haemorrhage is a global burden and is responsible for the majority of death of trauma who do
not reach the hospital and up to 40% of death of those who do. Thus, this study is to seek and
determine the possible effect of aqueous leaf extract of Terminalia catappa on haemostatic
indices of cyclophosphamide induced immunocompromised Wistar rats. Twenty five (25)
male Wistar rats were obtained The experimental rats were randomly divided into five (5)
groups. with five animals per group and treated for a period of fourteen (14) days. Group A:
NC (normal control) Group C: immune compromised rats treated with immunal (Standard
control) Group B: immune compromised rats (induced with cyclophosphamide) without
treatment (immune compromised control) Group D: immune compromised rats treated with
100 mg/kg bwt aqueous leaf extract 7. catappa extract (ALETCI) Group E: immune
compromised rats with 200 mg/kg bwt aqueous leaf extract 7. catappa extract (ALETC2) All
administrations were done orally using orpharyngeal cannula once per day for I4days (2
week). In conclusion the effect of aqueous extract of Terminalia catappa leaf to the
experimental animals are manifestation of its haematological possiblity of reversing the
damage done by cyclophosphamide induced immune compromised Wistar rats and thus can
be used as a therapeutic agent towards saving lives.
Full-Text Access Notice
In accordance with the NERD Policy on promoting peer-reviewed publication, public access to the full text of a project, thesis or dissertation is restricted for three years, allowing the author and supervisors sufficient time to pursue peer-reviewed publication.
During this period, researchers with legitimate academic or research purposes may request authorisation directly from the author to enable NERD to release the indexed full texts of the work using the form below.