EFFECT OF SUCRALOSE INGESTION ON THE LIVER ENZYMES ACTIVITIES IN DIABETIC MALE RATS
Abstract
Diabetes Mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin production or function, affecting lipid metabolism and organ. Increase in blood glucose level lead to acute complication like diabetic ketoacidosis and chronic complications such as cardiovascular disease, kidney failure. The study shows effect of sucralose on liver enzyme activities in diabetic male rats, focusing on liver toxicity markers, high-density lipoprotein (HDL) levels, alanine aminotransferase (ALT), and superoxide dismutase (SOD) activity using spectrophotometric techniques. The animals were divided into four groups: control group, diabetic group, sucralose-treated group and sucralose + diabetic group. Diabetes was induced using streptozotocin (45 mg/kg, i.p.) Sucralose was administered orally at a dose of 100 mg/kg body for 14 days. The results showed that ALT of sucralose fed group was lowered compared to diabetes and diabetes + sucralose group respectively. The Quinine Oxidase increases in diabetes group when compared to sucralose fed group but increase in diabetes + surculose group. Serum HDL level in diabetes group less increases when compared to sucralose fed group but significantly increase in Diabetes + sucralose group. Kidney SOD (Superoxide Dismutase) of diabetes groups decrease when compared to sucralose fed groups, however there is a increase in diabetes + sucralose groups when compare to diabetes groups. From the experiment it was observed that prolonged sucralose consumption could worsen liver function in diabetic conditions, possibly due to oxidative stress and alterations in lipid metabolism
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