EFFECT OF MANIHOT ESCULENTA CRANTZ (GARRI) ON OXIDATIVE STRESS AND PRO-INFLAMMATORY BIOMARKERS OF CASTOR OIL INDUCED DIARRHEA IN MALE WISTAR RATS
Abstract
Diarrhea is marked by increased stool frequency and fluidity, often caused by microbial
infections, inflammation, or gut dysfunction. The pathogenesis of diarrhea is closely linked to
oxidative stress and heightened pro-inflammatory cytokines, which compromise intestinal
integrity. Reactive oxygen species (ROS), such as superoxide and hydrogen peroxide, drive lipid
peroxidation and epithelial damage, while cytokines like TNF-α, IL-6, and IL-1β worsen mucosal
injury. Garri, a fermented cassava product consumed across Africa, is rich in carbohydrates and
bioactive compounds. Recent in vitro findings suggest it may possess antioxidant and antiinflammatory properties, possibly due to phenolic and fermentation-derived compounds. However,
there is limited in vivo evidence of its therapeutic potential. This study investigated the effect of
garri on oxidative stress and inflammation markers in a castor oil-induced model of diarrhea in
male Wistar rats.
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