EFFECT OF SODIUM ARSENITE ON THE HEART OF ADULT WISTAR RATS
Abstract
Sodium arsenite (NaAsO2) is a trivalent form of inorganic arsenic that is widely recognized for
its toxicological significance and environmental persistence. Arsenic contamination of
groundwater, particularly in regions like South Asia, has raised major public health concerns, as
millions of people are exposed to unsafe levels of arsenic through drinking water and food.This
study investigated the effect of sodium arsernite on the heart in adult Wistar rats.
A total of 31 adult Wistar rats were divided into four groups of eight animals each: a control
group receiving distilled water, a low-dose group receiving 50 mg/kg body weight of sodium
arsenite, a high-dose group receiving 100 mg/kg body weight of sodium arsenite and a very high
dose group receiving 150 mg/kg body weight of sodium arsenite. After 29 days of
administration, the rats were sacrificed. The heart was removed and weighed and then fixed
in10%formal calcium for histological studies. The tissue was processed,sectioned and stained
with hematoxylin and eosin for histological study.
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