HISTOLOGICAL EFFECT OF CEFIXIME ON THE LUNGS OF MALE ALBINO RATS.

This study was aimed at investigating the histological effect of cefixime on the lungs of Adult albino rat. Twenty four (24) rats with an average weight of 148 4.45 were randomly divided into four (4) groups of six (6) rats per cage. Group I (control) was treated with deionized distilled water and was fed daily for seven (7) days. Group II was administered daily oral doses of 2500mg/kg of cefixime daily for seven (7) days. Group III were treated with 5000mg/kg of cefixime daily for seven (7) days. Group IV were administered daily oral doses of 7500mg/kg of cefixime for seven (7) days. The body weight of the animal were determined before drug administration and twenty four (24) hours after the drug administration and recorded. The rats were sacrificed twenty four (24) hours after the last drug administration. The lungs were harvested and immediately fixed in 10% formal saline for histological studies. The tissue sections were routinely processed (paraffin wax technique). 5 micrometer section of each tissue were stained with H & E staining technique. Photo micro graphs of the slides were captured and result recorded. The result of this study revealed that Group I (control) had a mean weight of 1484.4g before the experiment and 151.22.88g after the experiment. Group II had a mean weight of 1404.83 before the experiment and 142.5 3.84g experiment and 150.0 2.291g after the experiment. Group IV had a mean weight Result obtained revealed that there was no statistical significant difference in their weights when compared to the control group (p>0.05) on the lungs of make albino rats. Conclusively, cefixime in this study on the lungs was found features of diffuse haemorrhage and moderate pulmonary congestion.