INVESTIGATING THE EFFECT OF ARTHROPTERIS PALISOTI EXTRACT ON HAEMOGLOBIN LEVEL IN MALARIA-INFECTED MICE
Abstract
Malaria continues to be a major global health issue, with more than three hundred million
infections and one million deaths every year. The alteration of hematological parameters is a
critical feature of malaria and can lead to severe hemorrhagic complications. Existing antimalarial
drugs primarily target the parasite but may not effectively address hematological
complications. Despite extensive efforts to control the disease, drug resistance and the
emergence of new Plasmodium strains remain persistent challenges, necessitating the
exploration of innovative therapeutic strategies. Medicinal plants contain a wide range of
secondary metabolites or compounds, including tannins, saponins, terpenoids, alkaloids, and
flavonoids, which play a crucial role in determining their therapeutic potential, particularly in
terms of antimicrobial activity. The study was conducted to investigate the impact of varying
doses of Arthropteris palisotii extract on haemoglobin levels in Swiss albino mice infected with
Plasmodium berghei NK65. Swiss albino mice were inoculated intraperitoneally with
| Plasmodium berghei NK65. The mice were grouped into six groups, six per group. Group |
were not infected with P. berghei, Group II and III served as both positive and standard controls
1 respectively, while Group IV, V, and VI were treated with 100, 200, and 400 mg/kg body weight
of Arthropteris palisotii extract respectively. After treatment period, all mice were sedated with
ketamine and dissected. Blood obtained by cardiac puncture using EDTA treated bottles, sterile
| syringes and needles. Blood platelets were measured using Sysmex KX-21 Hematology
Analyzer (Sysmex Corporation, Kobe, Japan) at the Heamatology Unit of University of
Calabar Teaching Hospital Laboratory, Calabar. The extract caused 14.3%, 36.3% and 69.2%
| suppression in parasitaemia at 100, 200 and 400mg/kg body weight respectively while
Artesunate exerted 10.1% suppression at 5Smg/kg body weight. There were significant decrease
(P
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