EFFECT OF AQUEOUS EXTRACT TERMINALIA CATTAPA LEAF ON LIVER SOD, CATALASE AND MDA IN CYCLOPHOSPAHAMIDE INDUCED IMMUNOCOMPROMIED WISTAR RATS
Abstract
Terminalia catappa is a medicinal plant with wide application in African traditional medicine for
| the management of several pathological conditions. This present research work was designed to
evaluate... The experimental rats were randomly divided into five (5) groups, with five animals
per group and treated for a period of fourteen (14) days. Group A: NC (normal control) Group
C: immune compromised rats treated with immunal (Standard control) Group B: immune
compromised rats (induced with cyclophosphamide) without treatment (immune compromised
control) Group D: immune compromised rats treated with 100mg/kg bwt aqueous leaf extract T.
catappa extract (ALETCI) Group E: immune compromised rats with 200mg/kg bwt aqueous
leaf extract T. catappa extract (ALETC2) All administrations were done orally using
orpharyngeal cannula once per day for 14 days (2 week). The extracts of Terminalia catappa
significantly lowered liver SOD, Catalase and MDA concentration at 200 and 400 mg/kg body
weight when compared with the normal and standard control. This suggests that extracts possess
the potential for reversing possible tissue oxidative damage caused by cyclophoamide as seen by
their abilities to prevent lipid peroxidation.
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