EFFECT OF LEAF EXTRACT OF ANDROGRAHIS PANICULATA ON HMG-COA REDUCTASE ACTIVITY IN STREPTOZOTOCIN INDUCED DIABETIC WISTAR RATS
Abstract
The effect of ethanol leaf extract of A. paniculata on liver tissue HMG-CoA reductase activities in STZ-induced diabetic Wistar rats was examined. Twenty five (25) Wistar rats were grouped (A) Normal control and (B) diabetic induced group. The rats were further grouped into: 1: Normal control animals fed with standard rat pellets and tap water II: Diabetic control, rats induced with streptozotocin and administered 0.2% tween 80 III: Diabetic rats treated with Metformin (200mg/kg body weight) IV: Diabetic rats administered with ethanol leaf extract of A. paniculata (500mg/kg body weight) V: Diabetic rats administered with ethanol leaf extract of A. paniculata (1000mg/kg body weight). The results revealed that there was higher activities (P0.05) difference in HMG-CoA reductase activity between groups of rats treated with Metformin and 500mg/kg bwt ethanol leaf extracts of A. pamiculata. This study revealed that A. paniculata could regulate dyslipidaemia occasioned by diabetic condition and could be used for the management of diabetes.
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