EFFECTS OF ALL-TRANS RETINOIC ACID (ATRA) ON GLUTAMATE AND ACETYLCHOLINESTERASE LEVEL IN FEMALE WISTAR RATS SUBJECTED TO INTESTINAL ISCHEMIA REPERFUSION INJURY INDUCED-COGNITIVE DEFICIT
Abstract
Intestinal ischemia reperfusion injury (IIRI) has been shown to affect distant organs such as the brain through oxidative stress and inflammatory mediators. This study investigated the effects of all-trans retinoic acid (ATRA) on glutamate and acetylcholinesterase levels in female Wistar rats subjected to IIRI-induced cognitive deficit. Sixty rats were divided into six groups and treated with low and high doses of ATRA. Results showed a significant increase in glutamate and AChE levels in IIRI groups, while ATRA-treated groups showed significant reductions. The findings suggest that ATRA has neuroprotective potential against IIRI-induced cognitive impairment.
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