EFFECT OF BIOSYNTHESIZED COPPER NANOPARTICLES ON OXIDATIVE STRESS AND KIDNEY FUNCTION IN MALE RATTUS NORVEGICUS
Abstract
This study explores the green synthesis of copper nanoparticles (CuNPs) using Scenedesnnts algae,
examining their biochemical and therapeutic effects in male albino rats under oxidative stress induced
by cadmium exposure. Characterization of the biosynthesized CuNPs through UV-Visible
spectroscopy, FTIR, and XRD analyses confirmed their structural integrity and potential bioactivity.
Experimental analysis showed that CuNP treatment significantly reduced markers of oxidative stress
such as malondialdehyde (MDA), while enhancing antioxidant enzyme activity, including
superoxide dismutase (SOD) and catalase (CAT), compared to cadmium-only treated groups. The
results indicate that CuNPs mitigated cadmium-induced toxicity by decreasing kidney damage
markers, such as alanine transaminase (ALT), aspartate transaminase (AST), and creatinine levels.
Additionally, hormonal assays revealed CuNPs' potential to alleviate disruptions in reproductive
hormones, as testosterone and luteinizing hormone (LH) levels were significantly higher in
CuNPtreated groups compared to the cadmium-only group. These findings suggest that
biosynthesized CuNPs could be a promising eco-friendly therapeutic intervention for managing
heavy metal-induced oxidative stress and associated biochemical dysregulation.
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