EFFECT OF METHANOLIC LEAF EXTRACT OF COLA MILLENI ON OXIDATIVE STRESS PARAMETERS IN STREPTOZOTOCIN INDUCED DIABETIC RATS
Abstract
Abstract
Diabetes mellitus is associated with increased oxidative stress, which contributes to its
complications such as retinopathy, neuropathy and nephropathy. This study aimed to evaluate the
effects of methanolic extract of Cola milleni on oxidative stress parameters in streptozotocin
induced diabetic rats. Streptozotocin was used to induce diabetes in rats, res ilting in elevated
oxidative stress parameters and diminished antioxidant defenses. The rats were administered
methanolic leaf extract of Cola milleni and metformin for 4 weeks. Results indicated that the
administration of Cola milleni extract led to a significant reduction in oxidative stress parameters,
including increased level of malondialdehyde concentration (p
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