SOME EFFECT OF CHROMIUM CHLORIDE ON THE LIVER OF ADULT WISTAR RATS.
Abstract
Chromium compounds are widely used in industrial and pharmaceutical applications, raising concerns about their potential toxicological effects on vital organs such as the liver. This study investigated the effects of chromium chloride on the liver of adult Wistar rats. Experimental animals were divided into control and treatment groups, with the treated groups receiving varying doses of chromium chloride over a specified period. At the end of the exposure, liver tissues were harvested for histological examination, while blood samples were analyzed for biochemical markers of liver function, including alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP).
Results indicated dose-dependent alterations in liver architecture, including hepatocellular degeneration, sinusoidal dilation, and inflammatory cell infiltration in treated groups compared to controls. Biochemical analysis revealed significant elevations in liver enzyme levels, suggesting impaired hepatic function. These findings demonstrate that chromium chloride exposure may induce hepatotoxic effects in adult Wistar rats, with severity dependent on dosage and duration of exposure.
In conclusion, chromium chloride has the potential to disrupt liver structure and function, highlighting the need for caution in its use and further studies to evaluate its safety profile in biological systems.
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