STUDIES ON EFFECTS OF VITAMIN E ON THE HISTOLOGY OF THE LIVER OF WISTAR RATS

The liver is a vital organ responsible for numerous physiological functions, including metabolizing fats, detoxifying harmful substances, and producing essential proteins. Vitamin E is a potent antioxidant, known to protect cell membranes from oxidative damage and reduce the risk of chronic liver diseases. Therefore, this study aimed to investigate the effect of vitamin E on the liver of Wistar rats. A total of twenty adults female Wistar rats were randomly divided into four groups: control, low-dose vitamin E, intermediate-dose vitamin E, and high-dose vitamin E. The experimental groups received vitamin E supplementation orally for three weeks, while the control group received a control diet without any supplementation. At the end of the intervention period, the liver tissue samples were collected for various analyses. Results revealed that vitamin E exerts protective effects on liver function. The histological liver result of the experimented rats shows that the liver of all the rats positively affected. It has been found to reduce lipid peroxidation and increase antioxidant enzyme activity, which helps to maintain liver health. In conclusion, vitamin E supplementation demonstrated beneficial effects on the liver of Wistar rats. It improved liver function, reduced fatty infiltrations, decreased oxidative stress, and enhanced antioxidant capacity. These findings suggest that vitamin E may have a protective role against liver damage and could be a potential therapeutic agent for liver-related disorders in humans. However, further investigations are necessary to validate these results and determine the optimal dosage for achieving maximum benefits.