BIOSYNTHESIS, CHARACTERIZATION OF COPPER NANOPARTICLES AND THEIR OXIDATION STRESS ON ALBINO RAT
Abstract
This study focuses on the green biosynthesis of copper nanoparticles (CuNPs) using plant extracts as a sustainable, eco-friendly approach, followed by their structural characterization and evaluation of oxidative stress induced in albino rats. The synthesis was confirmed via UV-Vis spectroscopy, and nanoparticles were characterized using SEM, XRD, and FTIR, revealing spherical, crystalline structures with a size range of 20-100 nm. Upon characterization, the CuNPs were administered to male albino rats to assess their in vivo toxicity. Results showed that elevated doses of CuNPs led to increased lipid peroxidation (MDA levels) and a significant reduction in antioxidant enzyme activities, such as SOD, GSH, and Catalase in the liver and kidneys. Histopathological examinations confirmed that high concentrations cause liver toxicity and oxidative stress-mediated cellular damage. While biosynthesized CuNPs offer potential bioapplications, this study demonstrates that they pose significant pro-oxidant risks at high exposures, requiring careful evaluation of dosage.
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