EFFECT OF BIOSYNTHESIZED COPPER NANOPARTICLES ON OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION OF MALE RATTUS NORVEGICUS
Abstract
This study focuses on the green synthesis of copper nanoparticles (CuNPs) using algal extracts
from Scenedesmus species and evaluates their biological effects on albino rats. Unlike
conventional synthesis methods, which often require toxic chemicals and high-energy processes,
green synthesis with algal extracts offers a more environmentally sustainable alternative. The
synthesized CuNPs were characterized by UV–visible spectroscopy, Fourier-transform infrared
(FTIR) spectroscopy, and X-ray diffraction (XRD) analysis, revealing distinct spectral features
that confirm the formation and stability of CuO nanoparticles. UV–visible spectroscopy showed
a characteristic absorption peak at around 380 nm, indicative of CuNP formation, while FTIR
analysis highlighted functional groups relevant to the nanoparticles’ surface interactions. To
assess the biological impacts, albino rats were treated with the synthesized CuNPs, and a range
of biomarkers were analyzed. Key findings include notable antioxidant activity, evidenced by
elevated levels of catalase and superoxide dismutase. Oxidative stress markers, such as
malondialdehyde (MDA), were also analyzed, with a reduction in MDA levels indicating
decreased lipid peroxidation and cellular oxidative damage.
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