EFFECT OF METHANOL NEEM SEED OIL EXTRACT ON MARKERS OF ACUTE RENAL INJURY IN MALE WISTAR RATS
Abstract
Acute renal injury (ARI) is a sudden decline in kidney function marked by impaired glomerular filtration, fluid retention, and the accumulation of nitrogenous waste products. Despite advances in modern therapeutics, there remains a growing interest in the use of medicinal plants such as Azadirachta indica (Neem) due to their perceived protective and antioxidant properties. This study was designed to evaluate the biochemical effects of methanol neem seed oil extract on acute renal injury in male Wistar rats.
A total of forty (40) healthy male Wistar rats, weighing between 170–240 g, were divided into four groups (n=10). Group 1 (Control) served as the control and received standard feed and water only, while Groups 2, 3, and 4 received 150mg/kg, 300mg/kg, and 600mg/kg of methanol neem seed oil extract, respectively, for five weeks. Serum creatinine and blood urea nitrogen (BUN) levels were measured to assess renal function. Statistical analysis was done using graph pad prism 5 (Graph Pad Software Inc., San Diego, CA), data were subjected to One Way Analysis of Variance with statistical significant set at P
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