COMPARATIVE ROLE OF OCCIMUM GRATISSIMUM AND VITAMIN C ON SERUM CHOLINESTERASE AND ALBUMIN CONC. IN POTASSIUM BROMATE INDUCED TOXICITY IN WISTAR RATS

Student: Emeka Lazarus Adie
Supervisor: Dr Victoria Edem Okon
HOD: Dr Ujong Gabriel Otu
Department of Physiology
Basic Medical Sciences
University of Cross River State, Calabar

Abstract

Ascorbic acid, often known as vitamin C, is a well-known antioxidant and free radical scavenger that is essential for lowering oxidative stress, promoting detoxification, and restoring antioxidant enzyme function (Niki, 2018). Vit C does not synthesized in human, because they lack the enzyme L-gulonolactone oxidase, so its sources are vegetables and fruits. Vit C is desired for collagen formation, maintaining healthy skin, gums and blood vessels, inorganic iron absorption, plasma cholesterol level reduction, and immune system inducement (Rekha et al., 2012). It protects the essential biological macromolecules from oxidative stress damage (Tawfik and Badr, 2012). Ocimum gratissimum is a viable natural option for reducing chemically induced toxicity since it has been shown to improve antioxidant defences, lower lipid peroxidation, and modify oxidative stress indicators (Akinmoladun et al., 2021). Comparative studies assessing the relative effectiveness of vitamin C and Ocimum gratissimum in recovering serum cholinesterase and albumin levels are still rare, despite their distinct advantages. 1.2 Statement

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